Advanced Screening And Tests for Assessing Infertility In Female And Male

Are you trying to get pregnant for a long time but so far, no luck? If a couple is unsuccessful at achieving pregnancy after trying for more than a year, it is recommended to undergo a thorough fertility screening and take the right assessment tests

At Apollo Fertility, the state-of-the-art infrastructure and advanced medical equipment facilitate a comprehensive fertility screening test for both females and males.

Female Diagnosis 

Ultrasound – Sonohysterogram (SHG) – It is an imaging procedure to study the uterus's shape and structure. Abnormal uterus shape, fibroid growth in the uterus or any other issues also cause fertility issues in a woman.

Endocrine Assessment: It is a hormone test for assessment of the entire endocrine system to analyse if there is any dysfunction causing infertility.

Ovarian Reserve Testing: The ovarian reserve measures the number of eggs in a female. It is a simple blood test that measures the levels of AMH (Anti-Mullerian Hormone) and AFC (Antral Follicle Count) that depicts the current ovarian reserve.

Tubal Assessment – Hysterosalpingogram – The HSG is a fluoroscope examination of the uterus and fallopian tubes. It helps identify the uterus morphology and investigates infertility or the cause of recurrent abortions.

Hysteroscopy: The procedure involves the insertion of a thin, flexible tube called a hysteroscope through the vagina. It examines the cervix and uterus for abnormalities.

HyCoSy/HyFoSy: HyCoSy (hysterosalpingo-contrast sonography) and HyFoSy (hysterosalpingo-foam sonography) is a diagnostic ultrasound procedures used for examining the uterine lining. The procedure also examines the health of the fallopian tubes.

Immunological Investigation: The test involves checking for immunological infertility, and the presence of pathological antisperm preventing fertilization of the egg and its embryo implantation.

Male Diagnosis 

Semen Analysis: The procedure is done to check for male fertility screening. It is also known as the sperm count test, which tests the health and viability of the sperm. It evaluates the sperm count, motility, morphology etc.

Post-ejaculation urinalysis: The test checks for sperm in the urine after ejaculation. The test is done when semen volume is low because of retrograde ejaculation, which is the backward flow of semen in the bladder rather than its flow out via the urethra.

Testicular Biopsy: The procedure involves testing a small tissue sample from the testicle to diagnose the cause of male infertility. The tissue portion is analyzed in a lab to detect the presence or absence of sperm.


Genetic Disorders: There are many genetic disorders like Kleinfelter syndrome, cystic fibrosis gene mutation, Noonan syndrome etc., in male and Fragile-X Syndrome, Kallmann Syndrome etc., in female that causes infertility. Comprehensive genetic disorder testing helps in finding underlying conditions. 

Genetic tests: There are underlying genetic issues that cause infertility in males and females. Advanced genetic testing helps in identifying the cause of infertility through proper assessment. 

PGT-A: It stands for preimplantation genetic testing for aneuploidy. The technique is used for screening for chromosomal abnormalities in eggs and embryos. It even helps in identifying birth defects such as Down Syndrome. 

PGT-SR: The PGT – SR (Structural rearrangement) is a genetic test that checks for chromosomal abnormality in embryos caused by specific structural rearrangement. 

PGT-M: It stands for Preimplantation genetic test – monogenic, and is a genetic test to check for chromosomal abnormality in the embryo. It helps in identifying conditions that might be inherited, like cystic fibrosis, beta thalassemia, muscular dystrophy etc.   

Chromosoma karyotyping: The genetic test evaluates the number and structure of chromosomes in an embryo to detect abnormalities. 

Endometrial Microbiota Analysis (EMMA/Alice): The human uterine endometrium has a balance of microbes, cellular immune response, and cytokines. The screening test or analysis checks for abnormal endometrial microbiota that might cause loss of pregnancy or implantation failure. 

Product of conception: This is the fetal or placental tissue that remains within the uterus after a miscarriage. The genetic screening of the product of conception helps in understanding if any issue leads to infertility. 

Sperm Anaploidy Screening: The diagnostic tool is a genetic test for men examining the sperm chromosome for abnormalities. It identifies the presence of defective chromosomes in the semen.

PGT – Pre genetic testing/ PGS – Pre genetic screening: The PGT/PGS are screening techniques that evaluate the chromosomal makeup of the embryo. Genetic testing screens for embryos before implantation reduces miscarriage rates and implantation failures. 

Sperm DNA Fragmentation Testing: DNA sperm fragmentation is one of the prominent causes of male infertility. DNA fragmentation testing measures the amount of damaged DNA in sperm. If there is a high percentage of damage, it causes difficulty in achieving pregnancy. 

You can request an appointment easily at Apollo Fertility, Kondapur, for a consultation by calling 1860 500 4424.

1.Why does the ovarian reserve decrease with age?

Low ovarian reserve means low egg count or few viable eggs. Ovarian reserve decline with age as the ovulation cycle diminishes. Also, the decline might be also due to genetics and other factors like hormonal imbalance or medical conditions.

2. What causes male infertility?

The most common cause of male infertility is hormonal imbalance leading to poor or low sperm count or blockages in male reproductive organs.

3. My husband and I are trying to conceive for over a year but, have not been able to. What to do?

It is recommended as per experts that if you are not able to conceive after 1 year of try with regular unprotected sexual intercourse, it is time for infertility evaluation.

4. What is the purpose of sonohysterogram (ultrasound)?

It is often a screening test for diagnosing the presence of female infertility. The procedure involves the study of a woman’s uterus shape and structure or the presence of any fibroid growth.

5. Can genetic abnormalities or disorders cause infertility?

Yes, genetic disorders or abnormalities might cause infertility. Advanced assessment and screening at Apollo Fertility Clinic, Kondapur helps in finding any underlying genetic issues.

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