Intra-Cytoplasmic Sperm Injection

Intra-Cytoplasmic sperm injection is a process where a sperm is injected directly into an egg to fertilize it. It's a highly successful procedure and you're doing great.

Intracytoplasmic sperm injection (ICSI) may result in a successful pregnancy for those who are infertile. When there are concerns with male infertility, this kind of in vitro fertilisation (IVF) is most beneficial. To facilitate conception, your doctor injects sperm into an egg. An embryo transfer may lead to pregnancy.

Who qualifies for Cytoplasmic sperm injection?

ICSI is most beneficial for men who are struggling with infertility. Your doctor could advise ICSI if you have any of the following conditions:

  • Anejaculation (inability to ejaculate) (inability to ejaculate).
  • Their male reproductive system is blocked.
  • The sperm count is low.
  • Sperm of poor quality.
  • Backward ejaculation (semen flows backwards into the bladder).

You might also require ICSI if:

  • Embryo formation has not occurred with conventional IVF.
  • The egg supplier is over 35 years old.
  • To try to get pregnant, you're using previously frozen sperm or eggs (cryopreservation).

Why is the ICSI procedure conducted?

This method is most frequently used to treat male infertility issues, while it may also be utilised in situations where eggs are difficult for sperm to enter and rarely in conjunction with sperm donation.

Because aberrant sperm morphology does not seem to affect blastocyst growth or morphology once the egg has been fertilised, it can be employed in teratozoospermia.

Microscopy can still identify the few sperm cells with a "normal" morphology even in cases of severe teratozoospermia, providing the best chance of success.

Benefits of ICSI 

Couples who have suffered from infertility may benefit from ICSI, particularly when male factors are involved. An improved fertilisation rate via ICSI during IVF can increase the number of fertilised eggs available for transfer or freezing. ICSI can boost the likelihood of successful fertilisation during standard insemination for couples dealing with male factor infertility (such as IUI).

Risks or complications of ICSI

  • Imprinting abnormalities are more likely to develop in IVF/ICSI kids. 53-56 Imprinting has a non-Mendalian effect on gene expression and the transmission of phenotypic syndromes or traits.
  • Gene flaws can cause childhood cancers, and some of these gene deficiencies are brought on by poor DNA mismatch repair. 
  • And last, the risk of autosomal and gonosomal aneuploidy is increased in IVF/ICSI progeny.
  • When compared to fertile males, infertile men have a 10-fold higher incidence of sperm aneuploidy. These aneuploidies most likely occur from homologous recombination in the testis and meiotic mistakes during synapsis.


Your doctor injects sperm into an egg to aid in fertilisation. If embryo development has not happened with standard IVF, you could also need ICSI. - The provider of eggs is older than 35. - You use previously frozen sperm or eggs to try to conceive (cryopreservation). It is possible to use abnormal sperm morphology in teratozoospermia because it does not appear to impair blastocyst growth or morphology once the egg has been fertilised. advantages of ICSI. 

ICSI may be beneficial for infertile couples, particularly when male factors are present. IVF/ICSI children are more likely to experience imprinting anomalies as risks or side effects. 53-56 On gene expression and the transfer of phenotypic syndromes or traits, imprinting has a non-Mendalian impact.

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1. When using ICSI, how long does it take for eggs to fertilize?

The incubator is refilled with the egg. In humans, fertilisation takes place in 4-6 hours, but no outward symptoms appear for another 17–18 hours. The formation of two spherical entities in the egg's centre is one of the first visible symptoms of fertilisation.

2. How can I tell whether ICSI is effective?

The fertilisation rate attained with the ICSI process appears to be the most crucial sign of ICSI success. The UCSF IVF lab has an outstanding fertilisation rate, which is currently between 80 and 85 per cent. In other words, eight out of every ten eggs will generally fertilise.

3. Are ICSI births on time?

Preterm Birth Risk Following IVF; Compared to singletons born naturally, IVF babies are roughly twice as likely to be born prematurely.

4. Do ICSI infants experience issues?

ICSI appears to carry a higher risk than traditional IVF for chromosomal abnormalities, autism, intellectual disability, and birth deformities. However, not all studies have found this link.

5. What distinguishes ICSI from conventional IVF?

A single sperm is injected directly into the centre of the egg during ICSI treatment, as opposed to the standard IVF procedure where about 200,000 sperm are placed next to the egg in a dish for fertilisation to occur.

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