Surprising! Infertility Too Can Have a Genetic Basis

November 3, 2023

Surprising! Infertility Too Can Have a Genetic Basis

Infertility is a common issue that affects many couples and it can be a frustrating and challenging experience. While there are several known causes of infertility, one surprising factor that you may not be aware of is its genetic basis.

Understanding the Genetic Basis of Infertility

  1. Genetics impacting fertility: Genetic factors can play a significant role in both female and male infertility. In some cases, genetic mutations or abnormalities can affect the production or function of reproductive cells, leading to difficulties in conception. These genetic issues may involve chromosomal abnormalities, gene mutations, or conditions that affect hormone levels or the development of reproductive organs.
  2. Inherited infertility: Certain fertility issues can be inherited from parents. For example, conditions like polycystic ovary syndrome (PCOS) and endometriosis have been found to have a genetic component. If either partner has a family history of these conditions, it's important to consult with a fertility specialist who can help identify potential genetic factors contributing to infertility.
  3. Specific genes related to infertility: Research has identified several genes associated with female and male infertility. For instance, mutations in the follicle-stimulating hormone receptor (FSHR) gene have been linked to problems with FSH receptors in women, affecting their ability to release mature eggs. In men, mutations in genes involved in sperm production and motility can lead to decreased sperm count or quality.

Addressing Genetic-Based Infertility

  1. Genetic testing: If you suspect that genetics may be a factor in your infertility, consult a fertility specialist to undergo genetic testing. This can help identify any specific genetic issue that could be affecting your ability to conceive. Genetic testing can be done for both partners and may involve analysing blood or saliva samples to look for gene mutations or chromosomal abnormalities.
  2. Assisted reproductive technologies: For couples with genetic-based infertility, various assisted reproductive technologies (ART) can offer hope. In vitro fertilisation (IVF) with preimplantation genetic testing (PGT) allows embryos to be screened for specific genetic abnormalities before implantation. This can help prevent the transmission of certain genetic conditions to future generations.
  3. Donor options: In cases where genetic factors make conception impossible or carry a high risk of passing on inheritable disorders, using donor eggs, sperm, or embryos may be a viable option. Working closely with a fertility specialist can help you explore these alternatives and make informed decisions based on your specific circumstances.

As you navigate the complex world of female and male infertility and genetics, remember that you are not alone. The team at Apollo Fertility will assist you at every step of the way. Schedule a consultation with our experienced fertility specialists to discuss your concerns and explore treatment options specific to your needs.

Can lifestyle choices impact genetic-based infertility?

While lifestyle choices do not directly cause genetic-based infertility, factors like smoking, excessive alcohol consumption, and poor diet can contribute to overall reproductive health issues. Maintaining a healthy lifestyle is important for optimising fertility potential.

Can genetic testing also reveal other health risks?

Yes, comprehensive genetic testing may uncover potential health risks beyond infertility. It can provide valuable insights into your overall health and help you take proactive measures to manage or prevent certain conditions.

Can genetic testing determine the success of assisted reproductive technologies like IVF or IUI?

Genetic testing can provide valuable insights into potential challenges and guide the selection of appropriate treatment options. However, the success of IVF procedure or IUI procedure depends on various factors, including age, overall health, and individual circumstances.

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